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The colors of my Photoshop canvas are not the same as my Save-to-Web output.

For example, #0000FF:
00F sample

I know there is something set wrong in the color profiles, but I can't figure out what is is.

The document is: sRGB IEC61966-2.1

My settings are: RGB: sRGB IEC61966-2.1

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post full screen of save for web and device part, there are some option in right hand side, just curious to see, might be something is there – Jack Sep 30 '11 at 7:48

I can't reproduce this problem with any usual settings. It's hard to tell from your screenshot exactly what's going on, since neither of those colors is #0000ff. The canvas color looks quite wrong, however, so I suspect either color proofing (View > Proof Colors or Ctl-Y) is turned on, or you need to reset your preferences (Ctl-Alt-Shift while the program is loading).

Try those and see if the problem resolves.

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