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What I'm looking for is a tool (online/offline) to create reviews for layouts (in my case: mobile applications layouts) - i.e. make comments/annotations for graphic designer that would be assigned to a view (PDF's page).

The perfect solution would also allow me to make comments for certain areas of a PDF, f.e. comment for an image acting as a button.

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up vote 1 down vote accepted

Adobe Acrobat Pro or Adobe Acrobat Standard both have a commenting feature which allows you to annotate any PDF and save the annotations.

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I found that this feature has to be enabled first. Something like "extend functionality". – KMSTR Sep 14 '12 at 10:24
The newest version of Adobe Reader, 'Adobe Reader X', also has this functionality, for free. – ΔλЛ Sep 15 '12 at 9:34

On the Mac, I find myself by-passing even Acrobat more and more and using the Apple Preview tool. They have pretty impressive PDF annotation capabilities these days as well.

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Be aware, Preview does not show all elements of some PDFs. There may be missing items in Preview which you aren't even aware of. – Scott Sep 18 '12 at 14:16

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