I have tried increasing the Snap distance, but even then, sometimes I accidentally move a guide when I'm trying to do a lot of repetitive tasks quickly.
Is there a way to lock guides in GIMP?
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No there isn't a way to lock the guides. However when using the Move tool you can hold down Shift when using the Move tool, so that the guide will not be able to be selected or moved accidentally.
This behaviour is documented in the user manual here