Yes, you can, but it's a significant amount of effort. If you're using blender, you need to master organic modeling with clean edge loops and topology, unwrapping, and rigging, just to get the model built.
If you want to do digital sculpture, you can do it in Blender, but I would recommend Zbrush since Zbrush is based entirely around high resolution sculpture. You have to master it's UI, creating complex meshes, clothing, anatomy, dynamic topology, how to sculpt realistic faces, bone landmarks where muscles begin and end, again, topology, starting from a low-res mesh, adding the maximum amount of detail, then working up to a high-res mesh. It's a ton of work.
THEN if you want to do it for games, you definitely have to be comfortable with retopologizing a high detail mesh, unwrapping that retopologized mesh, for every piece of clothing, then using somehting like xNormal or Marmoset to bake your high res model down to your low-res mesh. Then, you have to figure out specular maps and occlusion maps, etc. Actually, you have to figure out those things and how you're going to use them before you start, really.
It's a pretty insane process, and it doesn't pay well enough to be skilled at it tbh. That is, unless you've really mastered the process and can build something like what you see above and get it working in a game in a week, which is why I switched over to programming right after hitting the bottom line of being competent at the pipeline(getting things working properly with no errors other than art quality).
It's really rewarding though, and there's actually a lot you can do with 3D modeling skills. They're just real work to attain, make no mistake.