What functionality would I be looking at to remove the noise like below (from a histology image) within photoshop? I had hoped I would get around any complex neural filters to remove noise based on some pre-trained classifiers ...and this doesn't seem readily available in Photoshop (yet?).


Things I tried: Curve adjustment layers, like mentioned here, did not work to any degree of satisfaction for this, unfortunately. I tried the noise-reduction filters and dust-removal filters, but these approaches did not really target this kind of noise.

enter image description here

1 Answer 1


Image > Adjustments > Levels seems to work to a degree...

enter image description here

Call once to remove most of the noise. Then call again to boost the signal a bit more...

enter image description here

It's difficult to be definitive with only a small portion of any image. While what I've posted appears to help with the sample..... it may not work for the greater picture.

  • This is precisely the experience I'm having. I think I might even succeed making this work - will report back using levels, thanks a lot Commented Jan 14, 2021 at 13:19
  • This worked in the end, but very time-consuming method (if you want precise results). Alternatives would be welcome! Commented Jan 14, 2021 at 20:45

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