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Is there a way to save a photoshop file as a TIFF with multiple spot channels in CMYK mode?

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Yes. merely tick the Spot Colors option when saving the Tif with Photoshop...

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Whether or not those channels are visible, accessible, and separate properly in anything other than Photoshop may be another matter.

In most instances, saving as a .PSD, .PDF, or .DCS2 is best if you have spot channels.

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yes - save the spot colours as new channels - you can then bring them into illustrator and they'll be there as spot layers.

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  • Just note that if the plan is then place that Illustrator file into a layout application, such as InDesign or XPress... a Tiff will not "round trip" any spot colors from Illustrator. You need psd, dcs, or pdf for round trip spot colors.
    – Scott
    Oct 4 at 16:14

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