I am in the process of colouring a series of hand-drawn illustrations in Photoshop using a graphics tablet. The colouring process takes place mostly using Photoshop's native drawing tools - the pencil, airbrush, etc.
The final goal for these illustrations is printing on a digital offset printing machine.
My plan was to work in RGB colour space to have all of Photoshop's functions available, and worry about CMYK conversion at a very late point - or even sending RGB data to the printer's, letting them take care of the conversion and then fine-tune during the proof printing process.
Are there arguments from the world of professional print production that speak against this? Should I be taking CMYK into consideration much earlier so I don't use areas of the colour space that can never be reproduced on paper?