With most jobs it comes down to usually three things:
3) Good personal skills for the interview(s)
Education falls under experience. Actual real-world experience typically beats any college degrees (and this is usually demonstrated via one's portfolio). That being said, college degrees do help in getting you past the resume filters.
If you're lacking in any of these three areas, the best solution is to work on it. If the college degree is a reasonable (i.e. economical and feasible) possibility, take it. Or work on creating a nice portfolio. If you have some contacts with folks in the industry, call them and talk with them (or even better, meet with them). Do thank them for their time. If you don't have contacts, consider hanging around forums or places where these professionals congregate and just listen. You can learn a lot. And then ask smart questions. Soon you'll build up some connections with smart talented people working in the industry. If your personal soft skills are a bit weak, go to job fairs or career building events and practice, practice, practice until it becomes second nature to discuss the industry and how you'd like to be a part of it.
And one last final "magic" element - passion. If you really want to do this, let this passion shine out - not overbearing, but always there. People will note it and this can help open doors.