I have large techical drawing in PDF format with a lot of layers. But I only need three of these to be opened in Adobe Illustrator.
How do I delete layers from Layers panel in Acrobat Pro XI?
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Alternatively, there's a few entries in PDF fixups (Production/Preflight) to Remove Layers; the best for your question is this:
View > Tools > Print Production (Open) Hit Preflight Under the Profiles tab (top left), hit the little spanner/wrench icon in the top row. Double click [Remove layer with specified name] You'll be prompted for the name of the layer you wish to delete, and then a location to save your new PDF.
There is a really simple trick.
Hide the layer you want to delete
Use the Merge / Flatten menu from the "Options" button.
Then select two layers, one with visibility and the hidden one (which you want to delete)
Select the visible as the result and violà!
You will only have the visible layer and since the other one has hidden the content will be destroyed.