Unless you anticipate people taking it to be professionally printed it makes almost no difference.
Most people don't have calibrated monitors so the RGB doesn't look perfect, and people sure don't have high end printers and paper so the CMYK won't look perfect either. I wouldn't lose any sleep over either format. Go with whichever makes your life easier, if you don't need it to be professionally printed ever then probably RGB. If this is like a catalog that you're printing professionally but also putting online then just leave it in the CMYK you brought the printer, but please please please reduce the file size.