Someone using a graphics tablet with two monitors, what observations have you made about how a two monitor setup might need to affect one's choice of graphics tablet.
I'm buying something like this to be clear about what I mean by tablet:
nothing really changes when running 2 monitors. there are settings for the wacom (i've used the model pictured) that allow you to "crop" the working area of the tablet itself to mirror a single or dual monitor display. if you set it up to use on a dual monitor display, you'll effectively only use about half of the available working surface of the tablet.
every wacom i've ever used is highly customizable like that so i'm sure you can adjust it to work with your needs.