I'm developing technical graphics for a printed/online scientific publication using Adobe Illustrator CS5. I am trying to select a color palette that is pleasant when viewed in color and whose colors are distinguishable when printed in greyscale.
As an anti-example, suppose I have two colors: #942724 (red) and #265791 (blue). They are pleasant to look at, but when these are converted greyscale, they are completely indistinguishable.
I see that Illustrator comes with many Swatch Libraries and the Adobe Color Wheel provides six different color rules (e.g. Monochromatic, Analogous, Triad). It's easy to select, say, two colors that look good in color and are distinguishable in greyscale. But I find it much more difficult with 3+ colors. Is there a general technique/rule that can be applied? How does one select a color palette that is versatile enough to look good in color and be distinguishable in greyscale (or even B/W) print?