You could use a batch action in Photoshop.
Open up your first image in Photoshop and create a new action.
Crop the image at your desired size.
Flatten the image (I believe this is needed to stop Photoshop trying to save as a PSD, since anything with layers is assumed to be saved as a PSD. I havn't tested this extensively with a batch process so it may not be the case but assuming you're saving as an output raster format it isn't going to hurt.)
Stop recording your action.
Enable the "Show Dialog" option on the "Crop" command in your action in the Actions panel. This will pause the action before the crop is applied every time you run the action—allowing you to reposition. It will however remember the size and any other settings.
You can then create a batch process with your action by going to File → Automate → Batch... Simply choose your crop action under the "Play" section, Your folder of images under "Source" and an output under "Destination" (you can either choose a new folder or "Save and Close", which will overwrite the originals).
Your batch process will then pause on every crop so all you need to do is reposition and hit the enter key to continue. Repeat until finished.
You can read more about actions and batch processing in Photoshop here: