In one of my Photoshop projects, the client wanted to see some different variations of a specific area, so I needed to be able to select the exact same area every time.
To do this, I created a layer I call "Selection Mask", which is just filled with a colour outside the palette of the image. I set this layer as the top-most layer, and then draw a rectangle over the area I always wanted to copy. I then use the "Magic Wand" to select the block in this layer, then hide it so that I can see everything beneath it. I then CTRL + SHIFT + C (Copy Merged) to copy the visible content, and paste it in MSPaint with the other samples.
Is there a more effective way of doing this? I want to be able to close and reopen the image later on, and reselect the exact same area, partially for OCD reasons and partially because when I am done, I want the client to be able to put all the .png images in a folder, and left/right arrow through them and not have a layout change. (I numbered each version, so they can tell me what number they like best and I can build a better version of it.)
For what it's worth, the client is a user within the company (we don't have a graphic designer, so being one of the IT personnel somewhat acclimated with Photoshop and Illustrator, I usually get logo requests), who does not have Photoshop or any software that allows layered images, really.