I tried understanding the use of Blueprint CSS framework but could not gather much out of it.
There isn't software to do this well, mainly because it's such an inexact science. You can try your luck with the export to HTML function in PS, but that generally produces very bad code.
Blueprint and other CSS frameworks won't help you much if you are not that familar with CSS, it's really meant to lay down the basics for your layout, it won't help much if you aren't comfortable with working within CSS to begin with. Good luck.
Fireworks is better than Photoshop for this kind of work. Fireworks has always been a web design tool, whereas Photoshop was originally a tool for print designers.
Fireworks will open a PSD file and provides tools for creating interactive slices and the corresponding HTML. However like Wil says it is an inexact science and you will get much better results if you take the time to write your code by hand.